Husqvarna did some testing in the mid 70's that was very interesting. They put 3 identical stock engines on a dyno and ran them for several days at varying RPM and load conditions. Then both motors were torn down and inspected. The engine running CASTOR based oil had the least wear, followed by the synthetic oil, and finally the engine running standard 2-cycle oil.
A second test they performed was to run synthetic in 2 identical engines and one was run at 24:1, the other was run at 50:1 The engine that ran 24:1 had less piston skirt wear, and less rod bearing wear, but had the same main roller bearing wear as the engine run at 50:1.